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How to Use CBD Oil To Treat Migraines

CBD for Migraines

Intense migraine headaches can be both quite the literal pain. According to the Migraine Research Foundation, migraines are the third most common illness and the sixth most debilitating illness in the world. Every year, over 39 million people suffer from them in the U.S. alone. Migraines occur at some point in the lives of approximately 50% of women and 20% of men worldwide. It is a debilitating illness, capable of infringing upon your quality of life, mood, sleep, and in approximately 9 out of 10 sufferers, basic productivity.

Head pain can be such a prevalent major blight on life that the M.R.F. has approximated that Americans visit the emergency room for it every ten seconds. Of all those cases, around 1.2 million turned out to be acute migraines. Migraine headaches can be treated and alleviated through a variety of both pharmaceutical and non-pharmaceutical methods, but many of the most powerful painkilling drugs can sometimes plague patients with unwanted side effects. The Opioid Epidemic has been a long-publicized public health crisis in America, as have the side effects of opiates themselves. Conversely, other popular painkiller classes like NSAIDs are a little more benign and don’t risk habit-forming abuse, but they can bolster the risks of heart problems, internal bleeding, and organ failure when used frequently.

So if migraine sufferers don’t have much success with non-pharmaceutical treatments, where should they then turn to? Cannabidiol (CBD) has exploded onto the wellness scene as a versatile supplement designed to treat a multitude of symptoms. It just so happens that migraines and headache pain are among those symptoms. Read on to learn more.

The Research

Several studies have shown that cannabidiol is a highly effective generalized pain reliever, exhibiting a wide swath of anti-inflammatory, analgesic, apoptotic (malignant-cell killing) and neuropathic-healing properties. Moreover, CBD has also been demonstrated to induce neuroprotective properties, properties which a 2008 study found curbed over 50% of the effects in short-term neurodegenerative brain damage.

Granted, the above ‘08 study was done on pigs, but given what is known about the Endocannabinoid System present in every animal (more on that below), it’s logical to believe that similar results could be replicated in humans. Some researchers have also theorized that migraine headaches themselves may actually be the brain’s protective reaction to sensing these neurodegenerative states of oxidative stress. Regardless, why not reap the neuroprotective benefits without all the needless pain?

While little direct evidence exists about independent CBD use as a migraine treatment, one study conducted by the European Academy of Neurology found that 200mg of an oral CBD/THC hybrid formula was able to reduce up to 55 percent of cluster headache pain. Cluster headaches are amongst the most excruciating pain disorders known to man, often nicknamed “suicide headaches” for the ideations they can bring about. The fact that cannabinoids also could palliate something that severe should speak volumes about their potential to treat more run-of-the-mill migraines.

How CBD for Migraines Works

All CBD treatments fundamentally take effect through the same mechanisms. Every animal has a neurotransmitter network called the Endocannabinoid System. Chemical compounds known as cannabinoids can stimulate the ECS’ CB1 and CB2 cell receptors, and this stimulation can promote homeostasis in the body’s pained, unstable states. Lather, rinse, repeat over a variety of conditions, and these receptors can tackle all sorts of imbalance into equilibrium.

As for how exactly this interferes with migraines, there’s evidence that cannabinoids can inhibit trigeminovascular activation, a cerebral blood vessel nerve activation that is often associated with headaches. Some researchers, like Dr. Ethan Russo, have even theorized that clinical endocannabinoid deficiency could play a role in the cause of migraines, just as serotonin deficiency is widely believed to play a role in depression and anxiety. Furthermore, CB1 receptors have been shown to block pro-nociceptive (pain promoting) receptor signals in the nervous system, and it just so happens that the brain is an epicenter of CB1 receptors.

CBD Dose for Migraines

Depending on the severity and frequency of your migraines, you may need a higher dose of CBD. We recommend starting at a lower dose of CBD and working your way up to see how it affects your migraines.

Everyone is different, so please contact us if you have any questions about CBD dose for migraines.


CBD presents no major or dangerous side effects, but always be sure to do your research before buying to make sure a brand is reputable. When it comes to treating pain and migraines, full spectrum CBD is the best way to go, as you’ll get more benefits than isolate CBD, which contains less natural compounds. Our CBD is full spectrum, organic, and contains no pesticides or additives.

Contact us today if you have any questions about the best CBD for migraines or using our CBD to treat your migraines. 

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  • i just started using cbd to help my migraines. So far it seems to help!

    Sean Murphy on

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